Drug interactions
Carbidopa-entacapone-levodopa + Iloprost
Severity: Moderate
Carbidopa-entacapone-levodopa and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator and levodopa can cause orthostatic hypotension. Together they may produce additive blood pressure lowering, particularly with intravenous iloprost.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Iloprost belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of prostacyclin-mediated vasodilation and levodopa-related vasodilation and autonomic effects.
What to do
Monitor blood pressure and orthostatic symptoms during iloprost initiation and titration. Reduce the iloprost dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Iloprost?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator and levodopa can cause orthostatic hypotension. Together they may produce additive blood pressure lowering, particularly with intravenous iloprost.
How serious is the interaction between Carbidopa-entacapone-levodopa and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during iloprost initiation and titration. Reduce the iloprost dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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