Drug interactions
Amiodarone + Iloprost
Severity: Moderate
Amiodarone and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both iloprost, a prostacyclin vasodilator, and amiodarone can lower blood pressure. Together they may cause additive hypotension, especially with intravenous use.
What this interaction means in plain words
Amiodarone and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Iloprost belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Monitor blood pressure and heart rate when starting or titrating iloprost. Reduce the iloprost dose or hold other BP-lowering agents if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
- Carbidopa-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Amiodarone with Iloprost?
MediHelp rates the interaction as moderate. Amiodarone and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both iloprost, a prostacyclin vasodilator, and amiodarone can lower blood pressure. Together they may cause additive hypotension, especially with intravenous use.
How serious is the interaction between Amiodarone and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating iloprost. Reduce the iloprost dose or hold other BP-lowering agents if hypotension develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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