Drug interactions
Bupivacaine + Iloprost
Severity: Moderate
Bupivacaine and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupivacaine, especially with neuraxial block, can cause sympathetic blockade and hypotension, which may add to the vasodilation caused by iloprost.
What this interaction means in plain words
Bupivacaine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupivacaine belongs to Central Nervous System; Iloprost belongs to Cardiovascular.
Why it happens
Additive hypotension from prostacyclin vasodilation and local anesthetic-induced sympathetic blockade or cardiovascular effects.
What to do
Monitor blood pressure during and after anesthetic administration, and reduce the iloprost infusion rate if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupivacaine and Iloprost, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bupivacaine
- Bupivacaine + Bupivacaine implant Major
- Amlodipine-benazepril + Bupivacaine Moderate
- Benazepril + Bupivacaine Moderate
- Bupivacaine + Bupivacaine liposome Moderate
- Bupivacaine + Captopril Moderate
- Bupivacaine + Dofetilide Moderate
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
- Carbidopa-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Bupivacaine with Iloprost?
MediHelp rates the interaction as moderate. Bupivacaine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupivacaine, especially with neuraxial block, can cause sympathetic blockade and hypotension, which may add to the vasodilation caused by iloprost.
How serious is the interaction between Bupivacaine and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after anesthetic administration, and reduce the iloprost infusion rate if hypotension develops.
What other medicines interact with Bupivacaine?
MediHelp also lists interactions of Bupivacaine with, for example, Bupivacaine implant, Amlodipine-benazepril, Benazepril. The full list is on the Bupivacaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
