Drug interactions
Carbidopa-entacapone-levodopa + Irbesartan
Severity: Moderate
Carbidopa-entacapone-levodopa and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure and cause orthostatic hypotension, adding to irbesartan. Dizziness and falls may occur, especially at the start of treatment or after dose changes.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Irbesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of levodopa-derived dopamine and angiotensin receptor blockade.
What to do
Monitor sitting and standing blood pressure when either drug is started or adjusted. Reduce the irbesartan dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Irbesartan?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure and cause orthostatic hypotension, adding to irbesartan. Dizziness and falls may occur, especially at the start of treatment or after dose changes.
How serious is the interaction between Carbidopa-entacapone-levodopa and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when either drug is started or adjusted. Reduce the irbesartan dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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