Drug interactions
Carbidopa-entacapone-levodopa + Methohexital
Severity: Moderate
Carbidopa-entacapone-levodopa and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic that causes marked CNS depression and hypotension. Levodopa and entacapone can add to somnolence and hypotension, and levodopa-treated patients may have unstable blood pressure under anesthesia.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects (pharmacodynamic).
What to do
Inform the anesthesia team of dopaminergic therapy and monitor blood pressure and sedation depth closely. Avoid prolonged interruption of levodopa perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Methohexital
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Methohexital?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic that causes marked CNS depression and hypotension. Levodopa and entacapone can add to somnolence and hypotension, and levodopa-treated patients may have unstable blood pressure under anesthesia.
How serious is the interaction between Carbidopa-entacapone-levodopa and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of dopaminergic therapy and monitor blood pressure and sedation depth closely. Avoid prolonged interruption of levodopa perioperatively.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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