Drug interactions
Carbidopa-entacapone-levodopa + Oliceridine
Severity: Moderate
Carbidopa-entacapone-levodopa and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP3A4 and CYP2D6, so inhibitors can increase opioid exposure and respiratory depression. Entacapone is not an established CYP3A4 inhibitor, and levodopa may add sedation or hypotension. Opioids may also worsen constipation in Parkinson's disease.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and hypotensive effects, with a theoretical CYP3A4 inhibition by entacapone that is not well established.
What to do
Titrate oliceridine to effect, monitoring for sedation, respiratory depression and orthostatic hypotension. Use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Oliceridine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is metabolized by CYP3A4 and CYP2D6, so inhibitors can increase opioid exposure and respiratory depression. Entacapone is not an established CYP3A4 inhibitor, and levodopa may add sedation or hypotension. Opioids may also worsen constipation in Parkinson's disease.
How serious is the interaction between Carbidopa-entacapone-levodopa and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to effect, monitoring for sedation, respiratory depression and orthostatic hypotension. Use the lowest effective dose.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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