Drug interactions
Carbidopa-entacapone-levodopa + Treprostinil
Severity: Moderate
Carbidopa-entacapone-levodopa and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and levodopa can cause orthostatic hypotension. Together they may produce additive hypotension and dizziness.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering.
What to do
Monitor blood pressure, including standing readings, when starting or titrating either drug. Reduce the treprostinil dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Treprostinil?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and levodopa can cause orthostatic hypotension. Together they may produce additive hypotension and dizziness.
How serious is the interaction between Carbidopa-entacapone-levodopa and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or titrating either drug. Reduce the treprostinil dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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