Drug interactions
Carbidopa-levodopa + Fosinopril
Severity: Moderate
Carbidopa-levodopa and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa may cause orthostatic hypotension, and fosinopril adds to the blood pressure lowering effect. This may cause dizziness or falls, especially at the start of therapy.
What this interaction means in plain words
Carbidopa-levodopa and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Fosinopril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects of levodopa and ACE inhibition.
What to do
Monitor blood pressure, including standing readings, when either drug is started or adjusted. Reduce the fosinopril dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Carbidopa-levodopa with Fosinopril?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa may cause orthostatic hypotension, and fosinopril adds to the blood pressure lowering effect. This may cause dizziness or falls, especially at the start of therapy.
How serious is the interaction between Carbidopa-levodopa and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when either drug is started or adjusted. Reduce the fosinopril dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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