Drug interactions
Carbidopa-levodopa + Moexipril
Severity: Moderate
Carbidopa-levodopa and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure, and the ACE inhibitor moexipril adds to this effect. Orthostatic dizziness and falls may occur, especially at initiation.
What this interaction means in plain words
Carbidopa-levodopa and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Moexipril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotension from levodopa and ACE inhibition.
What to do
Monitor standing and sitting blood pressure after starting or changing either drug. Reduce the moexipril dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Carbidopa-levodopa with Moexipril?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure, and the ACE inhibitor moexipril adds to this effect. Orthostatic dizziness and falls may occur, especially at initiation.
How serious is the interaction between Carbidopa-levodopa and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure after starting or changing either drug. Reduce the moexipril dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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