Drug interactions
Carbidopa-levodopa + Oxybutynin
Severity: Minor
Carbidopa-levodopa and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is a relatively strongly anticholinergic agent that may delay levodopa absorption by slowing gastric emptying. It can also worsen confusion, constipation and cognitive impairment in patients with Parkinson disease.
What this interaction means in plain words
Carbidopa-levodopa and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-levodopa belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Antimuscarinic slowing of gastric emptying may delay levodopa absorption, with additive central anticholinergic effects.
What to do
Monitor cognition and levodopa response, and consider a less centrally acting bladder agent if confusion occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Oxybutynin
Frequently asked questions
Can I take Carbidopa-levodopa with Oxybutynin?
MediHelp rates the interaction as minor. Carbidopa-levodopa and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxybutynin is a relatively strongly anticholinergic agent that may delay levodopa absorption by slowing gastric emptying. It can also worsen confusion, constipation and cognitive impairment in patients with Parkinson disease.
How serious is the interaction between Carbidopa-levodopa and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and levodopa response, and consider a less centrally acting bladder agent if confusion occurs.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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