Drug interactions
Carbinoxamine + Chlordiazepoxide
Severity: Moderate
Carbinoxamine and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine; with a benzodiazepine it increases drowsiness, psychomotor impairment and confusion, especially in older adults.
What this interaction means in plain words
Carbinoxamine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and GABA-A potentiation.
What to do
Counsel patients about impaired alertness and avoid driving; consider a non-sedating antihistamine in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbinoxamine and Chlordiazepoxide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlordiazepoxide
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Carbinoxamine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine; with a benzodiazepine it increases drowsiness, psychomotor impairment and confusion, especially in older adults.
How serious is the interaction between Carbinoxamine and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about impaired alertness and avoid driving; consider a non-sedating antihistamine in at-risk patients.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
