Drug interactions
Carbinoxamine + Clemastine
Severity: Moderate
Carbinoxamine and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation sedating antihistamines, so taking them together duplicates therapy and increases drowsiness and anticholinergic effects such as dry mouth, urinary retention and confusion. Children and older adults are especially vulnerable.
What this interaction means in plain words
Carbinoxamine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Clemastine belongs to Respiratory.
Why it happens
Therapeutic duplication with additive H1 blockade and anticholinergic activity.
What to do
Avoid using two first-generation antihistamines together and choose a single agent. If both have been taken, monitor for sedation and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Clemastine?
MediHelp rates the interaction as moderate. Carbinoxamine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation sedating antihistamines, so taking them together duplicates therapy and increases drowsiness and anticholinergic effects such as dry mouth, urinary retention and confusion. Children and older adults are especially vulnerable.
How serious is the interaction between Carbinoxamine and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two first-generation antihistamines together and choose a single agent. If both have been taken, monitor for sedation and anticholinergic toxicity.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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