Drug interactions
Carbinoxamine + Fentanyl
Severity: Moderate
Carbinoxamine and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating antihistamine with anticholinergic properties that adds to the CNS depression caused by fentanyl. Combined anticholinergic and opioid effects can also promote urinary retention and severe constipation, which may progress to paralytic ileus.
What this interaction means in plain words
Carbinoxamine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive CNS depression and additive anticholinergic effects on gastrointestinal and urinary smooth muscle with opioid-induced reduction in motility.
What to do
Monitor for sedation, respiratory depression, urinary retention and constipation, and use the lowest effective doses. Consider a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Fentanyl?
MediHelp rates the interaction as moderate. Carbinoxamine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating antihistamine with anticholinergic properties that adds to the CNS depression caused by fentanyl. Combined anticholinergic and opioid effects can also promote urinary retention and severe constipation, which may progress to paralytic ileus.
How serious is the interaction between Carbinoxamine and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression, urinary retention and constipation, and use the lowest effective doses. Consider a non-sedating antihistamine if appropriate.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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