Drug interactions
Carbinoxamine + Ketamine
Severity: Moderate
Carbinoxamine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine. Combined with ketamine it may increase drowsiness, dizziness and psychomotor impairment. The effect is usually modest but can matter in procedural or outpatient settings.
What this interaction means in plain words
Carbinoxamine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Ketamine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation level and counsel the patient to avoid driving or operating machinery. Consider a non-sedating antihistamine if an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Ketamine?
MediHelp rates the interaction as moderate. Carbinoxamine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine. Combined with ketamine it may increase drowsiness, dizziness and psychomotor impairment. The effect is usually modest but can matter in procedural or outpatient settings.
How serious is the interaction between Carbinoxamine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and counsel the patient to avoid driving or operating machinery. Consider a non-sedating antihistamine if an antihistamine is needed.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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