Drug interactions
Carbinoxamine + Olanzapine
Severity: Moderate
Carbinoxamine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so combined use may lead to marked drowsiness, impaired psychomotor performance, dry mouth, constipation and urinary retention. The risk is greater in older adults.
What this interaction means in plain words
Carbinoxamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and muscarinic receptor blockade.
What to do
Counsel on drowsiness and avoiding driving or hazardous tasks. Consider a less sedating antihistamine, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Olanzapine?
MediHelp rates the interaction as moderate. Carbinoxamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so combined use may lead to marked drowsiness, impaired psychomotor performance, dry mouth, constipation and urinary retention. The risk is greater in older adults.
How serious is the interaction between Carbinoxamine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoiding driving or hazardous tasks. Consider a less sedating antihistamine, especially in elderly patients.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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