Drug interactions
Carbonyl iron + Didanosine
Severity: Minor
Carbonyl iron and Didanosine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations raise gastric pH, which can reduce dissolution and absorption of oral iron salts. Iron absorption may be lower, with a risk of poorer response to iron therapy.
What this interaction means in plain words
Carbonyl iron and Didanosine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbonyl iron belongs to Miscellaneous; Didanosine belongs to Anti Virals.
Why it happens
Increased gastric pH from buffering agents in didanosine reduces iron solubility and absorption.
What to do
Give iron at least 2 hours before didanosine buffered formulations, and monitor hemoglobin and iron indices.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Didanosine?
MediHelp rates the interaction as minor. Carbonyl iron and Didanosine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buffered didanosine formulations raise gastric pH, which can reduce dissolution and absorption of oral iron salts. Iron absorption may be lower, with a risk of poorer response to iron therapy.
How serious is the interaction between Carbonyl iron and Didanosine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give iron at least 2 hours before didanosine buffered formulations, and monitor hemoglobin and iron indices.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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