Drug interactions
Digoxin + Penicillamine
Severity: Moderate
Digoxin and Penicillamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
What this interaction means in plain words
Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Penicillamine belongs to Musculoskeletal.
Why it happens
Mechanism not established; reduced digoxin absorption has been suggested.
What to do
Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillamine
- Gold sodium thiomalate + Penicillamine Major
- Aluminum hydroxide + Penicillamine Moderate
- Calcium carbonate + Penicillamine Moderate
- Calcium + Penicillamine Moderate
- Carbonyl iron + Penicillamine Moderate
- Copper + Penicillamine Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Penicillamine?
MediHelp rates the interaction as moderate. Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
How serious is the interaction between Digoxin and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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