Drug interactions
Carboplatin + Colistin
Severity: Moderate
Carboplatin and Colistin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause kidney injury, and carboplatin is also associated with ototoxicity, though less than cisplatin. Together they may raise the risk of renal impairment, which can in turn increase carboplatin exposure and myelosuppression.
What this interaction means in plain words
Carboplatin and Colistin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Colistin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with possible additive ototoxicity.
What to do
Monitor serum creatinine and electrolytes regularly and adjust carboplatin dosing to renal function. Use an alternative to colistin if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b deoxycholate + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Colistin?
MediHelp rates the interaction as moderate. Carboplatin and Colistin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause kidney injury, and carboplatin is also associated with ototoxicity, though less than cisplatin. Together they may raise the risk of renal impairment, which can in turn increase carboplatin exposure and myelosuppression.
How serious is the interaction between Carboplatin and Colistin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes regularly and adjust carboplatin dosing to renal function. Use an alternative to colistin if feasible.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.
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