Drug interactions
Carboplatin + Neomycin
Severity: Moderate
Carboplatin and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carboplatin can cause kidney and hearing toxicity, and neomycin is highly nephrotoxic and ototoxic if absorbed. Oral neomycin is poorly absorbed, but absorption can increase with damaged gut mucosa or renal impairment, so additive toxicity is possible.
What this interaction means in plain words
Carboplatin and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Neomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and ototoxicity if neomycin is systemically absorbed.
What to do
Monitor renal function and hearing, especially with prolonged neomycin use, mucositis or renal impairment. Limit neomycin duration where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Neomycin?
MediHelp rates the interaction as moderate. Carboplatin and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carboplatin can cause kidney and hearing toxicity, and neomycin is highly nephrotoxic and ototoxic if absorbed. Oral neomycin is poorly absorbed, but absorption can increase with damaged gut mucosa or renal impairment, so additive toxicity is possible.
How serious is the interaction between Carboplatin and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing, especially with prolonged neomycin use, mucositis or renal impairment. Limit neomycin duration where possible.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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