Drug interactions
Carboplatin + Vancomycin
Severity: Moderate
Carboplatin and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can reduce kidney function, and carboplatin may also contribute to hearing loss and electrolyte disturbance. Together they may increase the risk of acute kidney injury and raise vancomycin exposure as clearance falls.
What this interaction means in plain words
Carboplatin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity from tubular injury, with reduced renal clearance of vancomycin and carboplatin.
What to do
Monitor serum creatinine, electrolytes and vancomycin trough or AUC levels, and adjust doses to renal function. Consider an alternative to vancomycin if suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Carboplatin
Frequently asked questions
Can I take Carboplatin with Vancomycin?
MediHelp rates the interaction as moderate. Carboplatin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can reduce kidney function, and carboplatin may also contribute to hearing loss and electrolyte disturbance. Together they may increase the risk of acute kidney injury and raise vancomycin exposure as clearance falls.
How serious is the interaction between Carboplatin and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and vancomycin trough or AUC levels, and adjust doses to renal function. Consider an alternative to vancomycin if suitable.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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