Drug interactions
Carboplatin + Voclosporin
Severity: Moderate
Carboplatin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and carboplatin is renally cleared with potential kidney toxicity. Together they may worsen renal function and increase carboplatin exposure and myelosuppression. Voclosporin is also immunosuppressive, adding to infection risk.
What this interaction means in plain words
Carboplatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with reduced carboplatin clearance and additive immunosuppression.
What to do
Monitor eGFR and serum creatinine frequently, and base the carboplatin dose on current renal function. Reduce or interrupt voclosporin per its labeling if renal function falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carboplatin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Carboplatin with Voclosporin?
MediHelp rates the interaction as moderate. Carboplatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, and carboplatin is renally cleared with potential kidney toxicity. Together they may worsen renal function and increase carboplatin exposure and myelosuppression. Voclosporin is also immunosuppressive, adding to infection risk.
How serious is the interaction between Carboplatin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum creatinine frequently, and base the carboplatin dose on current renal function. Reduce or interrupt voclosporin per its labeling if renal function falls.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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