Drug interactions
Itraconazole + Voclosporin
Severity: Contraindicated
Itraconazole and Voclosporin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole markedly raises voclosporin levels, increasing risks of nephrotoxicity, hypertension, neurotoxicity and QT prolongation. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Itraconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces metabolism of voclosporin, with possible additive QT effects.
What to do
Avoid the combination and use an alternative antifungal with less CYP3A4 inhibition, monitoring renal function if unavoidable exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
- Voclosporin + Voriconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Voclosporin?
MediHelp rates the interaction as contraindicated. Itraconazole and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises voclosporin levels, increasing risks of nephrotoxicity, hypertension, neurotoxicity and QT prolongation. Voclosporin labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antifungal with less CYP3A4 inhibition, monitoring renal function if unavoidable exposure occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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