Drug interactions
Cariprazine + Cenobamate
Severity: Moderate
Cariprazine and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and fatigue, so together they may increase sedation and impair coordination. Cenobamate is also a CYP3A4 inducer and may reduce cariprazine exposure.
What this interaction means in plain words
Cariprazine and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Cenobamate belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP3A4 induction by cenobamate increasing cariprazine metabolism.
What to do
Monitor for sedation and for loss of antipsychotic effect, and increase the cariprazine dose if clinically warranted. Titrate cenobamate slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Cenobamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Cenobamate
Frequently asked questions
Can I take Cariprazine with Cenobamate?
MediHelp rates the interaction as moderate. Cariprazine and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and fatigue, so together they may increase sedation and impair coordination. Cenobamate is also a CYP3A4 inducer and may reduce cariprazine exposure.
How serious is the interaction between Cariprazine and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of antipsychotic effect, and increase the cariprazine dose if clinically warranted. Titrate cenobamate slowly.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
