Drug interactions
Cariprazine + Clonidine
Severity: Moderate
Cariprazine and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, and cariprazine may cause orthostatic hypotension. Combined use may increase sedation and the risk of falls.
What this interaction means in plain words
Cariprazine and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Clonidine belongs to Cardiovascular.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure after initiation or dose changes. Counsel the patient on driving and rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Clonidine?
MediHelp rates the interaction as moderate. Cariprazine and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, and cariprazine may cause orthostatic hypotension. Combined use may increase sedation and the risk of falls.
How serious is the interaction between Cariprazine and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure after initiation or dose changes. Counsel the patient on driving and rising slowly.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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