Drug interactions
Cariprazine + Danazol
Severity: Moderate
Cariprazine and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a moderate CYP3A4 inhibitor and may raise exposure to cariprazine and its active metabolites, which have long half-lives. This can increase dose-related adverse effects such as akathisia, parkinsonism and sedation.
What this interaction means in plain words
Cariprazine and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cariprazine by danazol.
What to do
Monitor for extrapyramidal symptoms, akathisia and sedation, and consider reducing the cariprazine dose while danazol is used. Reassess when danazol is stopped, given the slow elimination of cariprazine metabolites.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Danazol?
MediHelp rates the interaction as moderate. Cariprazine and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a moderate CYP3A4 inhibitor and may raise exposure to cariprazine and its active metabolites, which have long half-lives. This can increase dose-related adverse effects such as akathisia, parkinsonism and sedation.
How serious is the interaction between Cariprazine and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia and sedation, and consider reducing the cariprazine dose while danazol is used. Reassess when danazol is stopped, given the slow elimination of cariprazine metabolites.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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