Drug interactions
Cariprazine + Diphenhydramine
Severity: Moderate
Cariprazine and Diphenhydramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine is a strongly sedating, anticholinergic antihistamine, and cariprazine can also cause somnolence. The combination may increase drowsiness, confusion and psychomotor impairment, particularly in older adults.
What this interaction means in plain words
Cariprazine and Diphenhydramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Diphenhydramine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic effects through H1 and muscarinic antagonism plus antipsychotic receptor blockade.
What to do
Avoid regular use in older adults and counsel on drowsiness and driving. Use a non-sedating antihistamine when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Cariprazine with Diphenhydramine?
MediHelp rates the interaction as moderate. Cariprazine and Diphenhydramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenhydramine is a strongly sedating, anticholinergic antihistamine, and cariprazine can also cause somnolence. The combination may increase drowsiness, confusion and psychomotor impairment, particularly in older adults.
How serious is the interaction between Cariprazine and Diphenhydramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use in older adults and counsel on drowsiness and driving. Use a non-sedating antihistamine when feasible.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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