Drug interactions
Cariprazine + Esketamine
Severity: Minor
Cariprazine and Esketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine can cause somnolence and akathisia, and esketamine causes sedation and dissociation. Together they may give additive drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Cariprazine and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cariprazine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Mild additive CNS depressant effects.
What to do
Monitor sedation and blood pressure during esketamine sessions; no routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Esketamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Esketamine
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Esketamine?
MediHelp rates the interaction as minor. Cariprazine and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cariprazine can cause somnolence and akathisia, and esketamine causes sedation and dissociation. Together they may give additive drowsiness and impaired psychomotor performance.
How serious is the interaction between Cariprazine and Esketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during esketamine sessions; no routine dose adjustment is needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
