Drug interactions
Cariprazine + Fentanyl iontophoretic transdermal system
Severity: Major
Cariprazine and Fentanyl iontophoretic transdermal system: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine and fentanyl both depress the CNS, so the combination may cause increased sedation, hypotension and respiratory depression. The risk is greatest in opioid-naive or debilitated patients.
What this interaction means in plain words
Cariprazine and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression from opioid agonism and antipsychotic sedation.
What to do
Limit use to patients for whom alternatives are inadequate and monitor for sedation and slowed breathing. Reduce doses if excessive drowsiness occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as major. Cariprazine and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cariprazine and fentanyl both depress the CNS, so the combination may cause increased sedation, hypotension and respiratory depression. The risk is greatest in opioid-naive or debilitated patients.
How serious is the interaction between Cariprazine and Fentanyl iontophoretic transdermal system?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to patients for whom alternatives are inadequate and monitor for sedation and slowed breathing. Reduce doses if excessive drowsiness occurs.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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