Drug interactions
Cariprazine + Flurazepam
Severity: Moderate
Cariprazine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with a long-lived active metabolite. With cariprazine it may cause additive sedation, impaired coordination, falls and next-day impairment.
What this interaction means in plain words
Cariprazine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antipsychotic receptor effects (pharmacodynamic).
What to do
Use the lowest effective flurazepam dose, preferably avoiding it in older adults, and monitor for daytime sedation. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Flurazepam?
MediHelp rates the interaction as moderate. Cariprazine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with a long-lived active metabolite. With cariprazine it may cause additive sedation, impaired coordination, falls and next-day impairment.
How serious is the interaction between Cariprazine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurazepam dose, preferably avoiding it in older adults, and monitor for daytime sedation. Counsel against driving and alcohol.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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