Drug interactions
Cariprazine + Gabapentin
Severity: Moderate
Cariprazine and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes somnolence, dizziness and ataxia, and cariprazine can add to these effects. The combination may increase impairment of alertness and coordination and the risk of falls, especially in older or frail patients.
What this interaction means in plain words
Cariprazine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through different pharmacodynamic pathways.
What to do
Start with low doses and titrate slowly, monitoring for sedation, dizziness and falls. Advise against driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Gabapentin
Frequently asked questions
Can I take Cariprazine with Gabapentin?
MediHelp rates the interaction as moderate. Cariprazine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin causes somnolence, dizziness and ataxia, and cariprazine can add to these effects. The combination may increase impairment of alertness and coordination and the risk of falls, especially in older or frail patients.
How serious is the interaction between Cariprazine and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, monitoring for sedation, dizziness and falls. Advise against driving until tolerance is established.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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