Drug interactions
Cariprazine + Insulin degludec / insulin aspart
Severity: Moderate
Cariprazine and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics including cariprazine can cause hyperglycemia and worsen glycemic control. This may reduce the effectiveness of insulin and raise insulin requirements.
What this interaction means in plain words
Cariprazine and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antipsychotic-associated impairment of glucose metabolism opposing insulin action (pharmacodynamic).
What to do
Monitor blood glucose more often when starting or adjusting cariprazine and adjust the insulin dose as needed. Monitor HbA1c and weight periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Cariprazine and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics including cariprazine can cause hyperglycemia and worsen glycemic control. This may reduce the effectiveness of insulin and raise insulin requirements.
How serious is the interaction between Cariprazine and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or adjusting cariprazine and adjust the insulin dose as needed. Monitor HbA1c and weight periodically.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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