Drug interactions
Cariprazine + Isoniazid
Severity: Minor
Cariprazine and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor and may modestly increase cariprazine and its active metabolites, which have long half-lives. Excess exposure could worsen adverse effects such as akathisia and sedation.
What this interaction means in plain words
Cariprazine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cariprazine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid decreasing cariprazine metabolism.
What to do
Monitor for extrapyramidal symptoms and sedation over several weeks. Reduce the cariprazine dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Isoniazid?
MediHelp rates the interaction as minor. Cariprazine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor and may modestly increase cariprazine and its active metabolites, which have long half-lives. Excess exposure could worsen adverse effects such as akathisia and sedation.
How serious is the interaction between Cariprazine and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation over several weeks. Reduce the cariprazine dose if adverse effects emerge.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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