Drug interactions
Cariprazine + Ketamine
Severity: Moderate
Cariprazine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine causes dissociation and sedation, and cariprazine can add somnolence and impaired cognition. Combined use may increase sedation, and the interplay between ketamine's psychotomimetic effects and antipsychotic treatment may be unpredictable.
What this interaction means in plain words
Cariprazine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive central nervous system effects through NMDA antagonism and dopamine/serotonin receptor modulation.
What to do
Use a conservative ketamine dose and monitor sedation level, blood pressure and psychiatric symptoms. Ensure supervised administration with resuscitation capability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Ketamine
Frequently asked questions
Can I take Cariprazine with Ketamine?
MediHelp rates the interaction as moderate. Cariprazine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine causes dissociation and sedation, and cariprazine can add somnolence and impaired cognition. Combined use may increase sedation, and the interplay between ketamine's psychotomimetic effects and antipsychotic treatment may be unpredictable.
How serious is the interaction between Cariprazine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a conservative ketamine dose and monitor sedation level, blood pressure and psychiatric symptoms. Ensure supervised administration with resuscitation capability.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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