Drug interactions
Cariprazine + Levorphanol
Severity: Major
Cariprazine and Levorphanol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is an opioid that causes sedation and respiratory depression. Combined with cariprazine, it may deepen CNS depression and impair alertness, and hypotension may also be more pronounced.
What this interaction means in plain words
Cariprazine and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression (pharmacodynamic).
What to do
Reserve the combination for patients who need both, using the lowest effective opioid dose and the shortest duration. Monitor sedation, respiratory rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Levorphanol?
MediHelp rates the interaction as major. Cariprazine and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is an opioid that causes sedation and respiratory depression. Combined with cariprazine, it may deepen CNS depression and impair alertness, and hypotension may also be more pronounced.
How serious is the interaction between Cariprazine and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients who need both, using the lowest effective opioid dose and the shortest duration. Monitor sedation, respiratory rate and blood pressure.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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