Drug interactions
Cariprazine + Lumacaftor / ivacaftor
Severity: Major
Cariprazine and Lumacaftor / ivacaftor: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may lower cariprazine and active metabolite exposure. This may reduce antipsychotic efficacy, although the net effect has not been quantified.
What this interaction means in plain words
Cariprazine and Lumacaftor / ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Lumacaftor induces CYP3A4, increasing clearance of cariprazine and its active metabolites.
What to do
Avoid if possible. If used, monitor for loss of psychiatric control and consider cariprazine dose adjustment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Lumacaftor / ivacaftor?
MediHelp rates the interaction as major. Cariprazine and Lumacaftor / ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumacaftor is a strong CYP3A inducer and may lower cariprazine and active metabolite exposure. This may reduce antipsychotic efficacy, although the net effect has not been quantified.
How serious is the interaction between Cariprazine and Lumacaftor / ivacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, monitor for loss of psychiatric control and consider cariprazine dose adjustment.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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