Drug interactions
Cariprazine + Meclizine
Severity: Moderate
Cariprazine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is a sedating antihistamine with anticholinergic activity, and cariprazine may also cause drowsiness. Used together they can increase sedation, dizziness and cognitive slowing, with a higher risk of falls in older adults.
What this interaction means in plain words
Cariprazine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive central nervous system depression from H1 antagonism and antipsychotic effects.
What to do
Advise caution with driving and use the lowest effective meclizine dose for the shortest time. Take extra care to prevent falls in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Meclizine
Frequently asked questions
Can I take Cariprazine with Meclizine?
MediHelp rates the interaction as moderate. Cariprazine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is a sedating antihistamine with anticholinergic activity, and cariprazine may also cause drowsiness. Used together they can increase sedation, dizziness and cognitive slowing, with a higher risk of falls in older adults.
How serious is the interaction between Cariprazine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise caution with driving and use the lowest effective meclizine dose for the shortest time. Take extra care to prevent falls in older patients.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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