Drug interactions
Cariprazine + Metoclopramide intranasal
Severity: Major
Cariprazine and Metoclopramide intranasal: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine D2 receptors, so together they raise the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Metoclopramide labeling cautions against use with antipsychotics.
What this interaction means in plain words
Cariprazine and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive dopamine D2 receptor antagonism.
What to do
Avoid the combination and use a non-dopamine-blocking antiemetic or prokinetic when possible. If used, monitor for movement disorders and fever or rigidity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Metoclopramide intranasal?
MediHelp rates the interaction as major. Cariprazine and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block dopamine D2 receptors, so together they raise the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Metoclopramide labeling cautions against use with antipsychotics.
How serious is the interaction between Cariprazine and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-dopamine-blocking antiemetic or prokinetic when possible. If used, monitor for movement disorders and fever or rigidity.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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