Drug interactions
Cariprazine + Nafcillin
Severity: Moderate
Cariprazine and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin appears to induce CYP3A4 and may lower cariprazine exposure. The effect is likely modest and temporary during a course of antibiotic therapy, but reduced efficacy is possible.
What this interaction means in plain words
Cariprazine and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, which may increase cariprazine clearance.
What to do
Monitor psychiatric symptoms during and for some weeks after nafcillin therapy and adjust the cariprazine dose if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Nafcillin?
MediHelp rates the interaction as moderate. Cariprazine and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin appears to induce CYP3A4 and may lower cariprazine exposure. The effect is likely modest and temporary during a course of antibiotic therapy, but reduced efficacy is possible.
How serious is the interaction between Cariprazine and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms during and for some weeks after nafcillin therapy and adjust the cariprazine dose if response declines.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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