Drug interactions
Cariprazine + Olanzapine
Severity: Moderate
Cariprazine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics adds to sedation, orthostatic hypotension, extrapyramidal symptoms and metabolic adverse effects. Olanzapine in particular is strongly sedating and associated with weight gain and glucose dysregulation. No major pharmacokinetic interaction is expected.
What this interaction means in plain words
Cariprazine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from multiple dopamine, serotonin, histamine and adrenergic receptor actions.
What to do
Reserve combination for patients not adequately treated with one agent, using the lowest effective doses. Monitor sedation, movement disorders, weight, glucose and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Olanzapine
Frequently asked questions
Can I take Cariprazine with Olanzapine?
MediHelp rates the interaction as moderate. Cariprazine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics adds to sedation, orthostatic hypotension, extrapyramidal symptoms and metabolic adverse effects. Olanzapine in particular is strongly sedating and associated with weight gain and glucose dysregulation. No major pharmacokinetic interaction is expected.
How serious is the interaction between Cariprazine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combination for patients not adequately treated with one agent, using the lowest effective doses. Monitor sedation, movement disorders, weight, glucose and lipids.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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