Drug interactions
Cariprazine + Pentobarbital
Severity: Major
Cariprazine and Pentobarbital: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may lower cariprazine and active metabolite concentrations. It also adds central nervous system depression, so efficacy loss and sedation are both concerns.
What this interaction means in plain words
Cariprazine and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate induction of CYP3A4 increases cariprazine clearance, plus additive CNS depression.
What to do
Avoid long-term combination where possible. If used, monitor for reduced antipsychotic effect and excess sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Pentobarbital?
MediHelp rates the interaction as major. Cariprazine and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentobarbital induces CYP3A4 and may lower cariprazine and active metabolite concentrations. It also adds central nervous system depression, so efficacy loss and sedation are both concerns.
How serious is the interaction between Cariprazine and Pentobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination where possible. If used, monitor for reduced antipsychotic effect and excess sedation.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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