Drug interactions
Cariprazine + Phenobarbital
Severity: Major
Cariprazine and Phenobarbital: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an established CYP3A4 inducer that may lower cariprazine and active metabolite concentrations, risking relapse. Its sedative effect also adds to that of cariprazine.
What this interaction means in plain words
Cariprazine and Phenobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Phenobarbital induces CYP3A4, increasing clearance of cariprazine and its active metabolites, plus additive CNS depression.
What to do
Avoid if possible, as labeling advises against strong CYP3A4 inducers. If necessary, monitor for loss of efficacy and sedation and adjust the cariprazine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Phenobarbital?
MediHelp rates the interaction as major. Cariprazine and Phenobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenobarbital is an established CYP3A4 inducer that may lower cariprazine and active metabolite concentrations, risking relapse. Its sedative effect also adds to that of cariprazine.
How serious is the interaction between Cariprazine and Phenobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, as labeling advises against strong CYP3A4 inducers. If necessary, monitor for loss of efficacy and sedation and adjust the cariprazine dose.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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