Drug interactions
Cariprazine + Pimozide
Severity: Moderate
Cariprazine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics that cause sedation, and each can also affect cardiac conduction and extrapyramidal function. Combining them raises the risk of additive somnolence, extrapyramidal symptoms and possibly QT effects.
What this interaction means in plain words
Cariprazine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive dopamine receptor antagonism and CNS depression.
What to do
Avoid concurrent antipsychotics where possible. If used together, monitor for sedation and movement disorders and consider baseline and follow-up ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Pimozide?
MediHelp rates the interaction as moderate. Cariprazine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antipsychotics that cause sedation, and each can also affect cardiac conduction and extrapyramidal function. Combining them raises the risk of additive somnolence, extrapyramidal symptoms and possibly QT effects.
How serious is the interaction between Cariprazine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent antipsychotics where possible. If used together, monitor for sedation and movement disorders and consider baseline and follow-up ECG.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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