Drug interactions
Cariprazine + Remifentanil
Severity: Moderate
Cariprazine and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remifentanil is a potent opioid and cariprazine is an antipsychotic with sedating properties. Used together they can add to drowsiness, psychomotor impairment and respiratory depression. The risk is greatest with higher doses and in frail or opioid-naive patients.
What this interaction means in plain words
Cariprazine and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Titrate remifentanil to the lowest effective rate and monitor sedation level and respiratory status continuously. Reduce doses of one or both agents if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Remifentanil?
MediHelp rates the interaction as moderate. Cariprazine and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remifentanil is a potent opioid and cariprazine is an antipsychotic with sedating properties. Used together they can add to drowsiness, psychomotor impairment and respiratory depression. The risk is greatest with higher doses and in frail or opioid-naive patients.
How serious is the interaction between Cariprazine and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remifentanil to the lowest effective rate and monitor sedation level and respiratory status continuously. Reduce doses of one or both agents if excess sedation occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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