Drug interactions
Carisoprodol + Clobazam
Severity: Major
Carisoprodol and Clobazam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and carisoprodol together cause additive CNS depression, which may result in marked sedation, impaired coordination and respiratory depression. Carisoprodol can also modestly affect CYP2C19 activity, which may alter clobazam's active metabolite exposure.
What this interaction means in plain words
Carisoprodol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A enhancement.
What to do
Avoid the combination where possible, or use the lowest effective doses and monitor for sedation and respiratory depression. Counsel against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carisoprodol
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
- Clobazam + Codeine Major
Frequently asked questions
Can I take Carisoprodol with Clobazam?
MediHelp rates the interaction as major. Carisoprodol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines and carisoprodol together cause additive CNS depression, which may result in marked sedation, impaired coordination and respiratory depression. Carisoprodol can also modestly affect CYP2C19 activity, which may alter clobazam's active metabolite exposure.
How serious is the interaction between Carisoprodol and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective doses and monitor for sedation and respiratory depression. Counsel against alcohol and driving.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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