Drug interactions
Amobarbital + Clobazam
Severity: Major
Amobarbital and Clobazam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates with benzodiazepines increase the risk of profound sedation, respiratory depression and coma. Barbiturate induction may also lower clobazam levels while raising its active metabolite proportion.
What this interaction means in plain words
Amobarbital and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression; enzyme induction alters clobazam metabolism.
What to do
Use the lowest effective doses and monitor sedation and respiratory status, especially at initiation. Avoid alcohol and other depressants.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Clobazam
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
- Clobazam + Codeine Major
Frequently asked questions
Can I take Amobarbital with Clobazam?
MediHelp rates the interaction as major. Amobarbital and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates with benzodiazepines increase the risk of profound sedation, respiratory depression and coma. Barbiturate induction may also lower clobazam levels while raising its active metabolite proportion.
How serious is the interaction between Amobarbital and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status, especially at initiation. Avoid alcohol and other depressants.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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