Drug interactions
Carisoprodol + Cyclizine
Severity: Moderate
Carisoprodol and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine, and with carisoprodol it may cause additive drowsiness and reduced psychomotor performance.
What this interaction means in plain words
Carisoprodol and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Cyclizine belongs to Respiratory.
Why it happens
Additive CNS depression via central H1 antagonism and carisoprodol's sedative effect.
What to do
Counsel against driving and alcohol, and monitor for excess sedation, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Carisoprodol with Cyclizine?
MediHelp rates the interaction as moderate. Carisoprodol and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine, and with carisoprodol it may cause additive drowsiness and reduced psychomotor performance.
How serious is the interaction between Carisoprodol and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against driving and alcohol, and monitor for excess sedation, especially in older adults.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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