Drug interactions
Carisoprodol + Doxepin
Severity: Moderate
Carisoprodol and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, and combining it with carisoprodol can increase drowsiness, dizziness and psychomotor impairment. Anticholinergic effects of doxepin may add to confusion in older adults. Higher doses of doxepin increase this concern.
What this interaction means in plain words
Carisoprodol and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression through histaminergic blockade by doxepin and GABA-A-mediated sedation by carisoprodol/meprobamate.
What to do
Use the lowest effective doses and caution the patient about driving and falls. Monitor for oversedation, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carisoprodol and Doxepin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carisoprodol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Carisoprodol with Doxepin?
MediHelp rates the interaction as moderate. Carisoprodol and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, and combining it with carisoprodol can increase drowsiness, dizziness and psychomotor impairment. Anticholinergic effects of doxepin may add to confusion in older adults. Higher doses of doxepin increase this concern.
How serious is the interaction between Carisoprodol and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and caution the patient about driving and falls. Monitor for oversedation, particularly in older adults.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
