Drug interactions
Carisoprodol + Metaxalone
Severity: Moderate
Carisoprodol and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are centrally acting skeletal muscle relaxants with sedating effects. Using them together gives no therapeutic advantage and increases drowsiness, dizziness and impaired coordination.
What this interaction means in plain words
Carisoprodol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Avoid concurrent use of two muscle relaxants and choose a single agent. If overlap occurs, monitor for sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Metaxalone
Frequently asked questions
Can I take Carisoprodol with Metaxalone?
MediHelp rates the interaction as moderate. Carisoprodol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are centrally acting skeletal muscle relaxants with sedating effects. Using them together gives no therapeutic advantage and increases drowsiness, dizziness and impaired coordination.
How serious is the interaction between Carisoprodol and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two muscle relaxants and choose a single agent. If overlap occurs, monitor for sedation and falls.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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