Drug interactions
Carisoprodol + Oxymorphone
Severity: Major
Carisoprodol and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with carisoprodol can cause marked sedation, dizziness and respiratory depression. Misuse and overdose risk is higher with this combination, particularly when a benzodiazepine is also taken.
What this interaction means in plain words
Carisoprodol and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression; carisoprodol and its metabolite meprobamate have GABA-A-mediated sedative effects.
What to do
Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and counsel against alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Carisoprodol
Frequently asked questions
Can I take Carisoprodol with Oxymorphone?
MediHelp rates the interaction as major. Carisoprodol and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with carisoprodol can cause marked sedation, dizziness and respiratory depression. Misuse and overdose risk is higher with this combination, particularly when a benzodiazepine is also taken.
How serious is the interaction between Carisoprodol and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and counsel against alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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