Drug interactions
Carisoprodol + Sparsentan
Severity: Moderate
Carisoprodol and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2C19, which converts carisoprodol to meprobamate. Carisoprodol exposure may fall, while meprobamate formation may rise, changing efficacy and sedation.
What this interaction means in plain words
Carisoprodol and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carisoprodol belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
CYP2C19 induction by sparsentan increases carisoprodol metabolism.
What to do
Monitor for reduced muscle relaxant effect and for sedation from meprobamate; adjust the carisoprodol dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Carisoprodol with Sparsentan?
MediHelp rates the interaction as moderate. Carisoprodol and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP2C19, which converts carisoprodol to meprobamate. Carisoprodol exposure may fall, while meprobamate formation may rise, changing efficacy and sedation.
How serious is the interaction between Carisoprodol and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced muscle relaxant effect and for sedation from meprobamate; adjust the carisoprodol dose as needed.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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